Enhanced dissolution and absorption of trimethoprim from coprecipitates with polyethylene glycols and polyvinylpyrrolidone

Abstract

Coprecipitates of trimethoprim have been prepared by solvent method using polyethylene glycols 4000, 6000 and 9000, and polyvinylpyrrolidone (M.W. 40,000) as water soluble carriers. A marked increase in the dissolution rate of trimethoprim in the coprecipitates was observed compared with that of the drug alone. Coprecipitates with polyethylene glycol 6000 (1:2) showed faster release as well as bioavailability of the drug in human volunteers.