Science · 1977 · 65 citations · 23 references
Life SciencesNeurobiologyNeuroscienceBehavioral NeuroscienceNeurochemistryNeuropharmacologyDopaminergic SignalingMonoamine NeurochemistryNeural StimulationNeuromodulationNeurostimulationReward PathwaysDopaminergic CircuitsDopaminergic NeurophysiologyDopaminergic PathwaysElectrical StimulationIn Vivo StudiesMesocortical Dopamine SystemPrefrontal Cortex FunctionPrefrontal Cortex Involvement
Rats were trained to self-stimulate the medial prefrontal cortex, a region rich in dopaminergic terminals. After the region adjacent to the electrode site was labeled with [14C]dopamine, it was perfused repeatedly by means of push-pull cannulas. Electrical stimulation of this cortical area in six animals enhanced the release of dopamine and its associated metabolites in nine of 16 experiments. Thus in vivo evidence is provided that dopamine is involved in the brain self-stimulation mechanism within the frontal cortex.
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Selective activation of the mesocortical DA system by stress
A.M. Thierry, Jean‐Pol Tassin, Gérard Blanc et al. · Nature · 1976 · 1K citations
Drugs, Neurotransmitters, and Schizophrenia
Solomon H. Snyder, Shailesh P. Banerjee, Henry I. Yamamura et al. · Science · 1974 · 835 citations
Medicine, Neuroscience, Pharmacology +16
Mesencephalic dopamine neurons projecting to neocortex
Olle Lindvall, Anders Björklund, Robert Y. Moore et al. · Brain Research · 1974 · 505 citations
Dopaminergic Terminals in the Rat Cortex
A.M. Thierry, Gérard Blanc, A Sobel et al. · Science · 1973 · 503 citations