THE CYTOKINE AND HISTOLOGICAL RESPONSE IN ISLET XENOGRAFT REJECTION IS DEPENDENT UPON SPECIES COMBINATION1

Abstract

The mouse used different mechanisms to reject the rat and canine islets, suggesting that the immune response in islet xenograft rejection may be dependent on the species combination. It may not be possible to characterize the cellular xenograft rejection response in a bipolar manner as has been the case with humoral rejection response. Caution therefore needs to be taken before extrapolating the cellular immune responses seen in animal models to the clinical setting.