Chiral Recognition inside a Chiral Cucurbituril

Abstract

Picky host: The isolation, characterization, and recognition properties of the first chiral cucurbit[n]uril—(±)-bis-nor-seco-CB[6]—are reported. The (±)-bis-ns-CB[6] undergoes diastereoselective recognition events with guests that contain stereogenic centers including amino acids, amino alcohols, and meso compounds.