Pharmacological characteristics of Ro 115–1240, a selective α _1A/1L ‐adrenoceptor partial agonist: a potential therapy for stress urinary incontinence

Abstract

These results show that by combining selectivity for the alpha1A/1L-AR subtype with a reduction in intrinsic agonist efficacy, Ro 115-1240 has reduced haemodynamic effects while retaining to some degree the contractile effects on urethral smooth muscle. These studies indicate that Ro 115-1240 may be useful as a novel treatment for SUI.