SYNTHESIS OF THE MERRIFIELD RESIN ESTERS OF N-PROTECTED AMINO ACIDS WITH THE AID OF HYDROGEN BONDING1

Abstract

Abstract A synthesis of the Merrifield resin esters of N-protected amino acids was attempted with the aid of hydrogen-bonding property of fluoride ion with carboxylic acids to obtain the esters in satisfactory yields. This will provide an alternatively efficient and economical method for the preparation of the key intermediate of the solid phase peptide synthesis.