Differential Effects of an Anti-Oxidant Intervention on Cardiomyocyte Expression of Adrenomedullin and Intermedin and their Receptor Components in Chronic Nitric Oxide Deficiency

Abstract

normalization specifically of augmented IMD/RAMP1 expression in NO-deficient cardiomyocytes by antioxidant intervention in the absence of blood pressure reduction indicates that these genes are likely to be induced directly by myocardial oxidative stress. Although oxidative stress contributed to cardiomyocyte hypertrophy, induction of IMD and RAMP1 is unlikely to be secondary to cardiomyocyte hypertrophy.