Journal of Veterinary Medical Science · 2004 · 59 citations · 16 references
Life SciencesNeurologyNeuroscienceNeurodegenerationNeuroimmunologyNeuropathologyAutoantibody-mediated DiseaseAutoimmune Neurological DisordersBrain TumorsCerebrospinal Fluid BiomarkersCerebrospinal Fluid ImmunologyNeuroinflammationCerebrospinal Fluid AnalysisCerebrospinal Fluid Antibody TestingCerebrospinal Fluid AutoantibodiesCerebrospinal Fluid DiagnosisGranulomatous MeningoencephalitisIndirect Fluorescent Antibody AssayNecrotizing MeningoencephalitisSerum Autoantibody Testing
To examine the prevalence of autoantibody in canine cerebrospinal fluids (CSFs), CSFs were collected from 14 healthy controls and 88 clinical cases with various diseases in the central nervous system (CNS), and were analyzed by an indirect fluorescence antibody test on frozen sections of the cerebrum from normal Beagle dogs. An anti-astrocyte autoantibody was detected in 31 clinical cases with titers ranging from 1:1 to >/=1:100. All tested cases with necrotizing meningoencephalitis (NME: n=22) and granulomatous meningoencephalitis (GME: n=3) possessed the anti-astrocyte autoantibody, while the autoantibody was negative in most cases with other inflammatory CNS diseases. The autoantibody was also detected in 4 of 12 cases with brain tumors. Hence, examination of the autoantibody in the canine CFS would be significant for diagnosing NME and/or GME, as well as for understanding peritumoral events in cases with brain tumors.
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Autoantibodies to Glutamate Receptor GluR3 in Rasmussen's Encephalitis
Scott W. Rogers, P. Ian Andrews, Lorise C. Gahring et al. · Science · 1994 · 688 citations