Serotonin decreases HIV‐1 replication in primary cultures of human macrophages through 5‐HT_1A receptors

Abstract

The effects of 5-HT on HIV infection could be a consequence of the increase in MIP-1alpha concentrations and/or CCR5 receptor downregulation. These results suggest that 5-HT can inhibit the replication of HIV-1 in primary culture of human macrophages through its action on 5-HT(1A) receptors.