Thrombosis Detection by Radionuclide Particle (MAA) Entrapment: Correlation with Fibrinogen Uptake and Venography

Abstract

Macroaggregated albumin (MAA) entrapment in areas of fibrin deposits has been used to detect intravenous thrombosis in the lower extremities. This study reports the correlation of MAA uptake in thrombosis with venography and autologous 125I-labeled fibrinogen uptake in approximately 30 cases. Correlation was good in most patients who underwent at least two of these procedures. The MAA thrombosis scan appears especially accurate in locating thrombosis in the upper thigh or pelvis where fibrinogen uptake is less helpful. The correlation suggests that the MAA scan has very few false negative results. The procedure is easily performed in conjunction with a perfusion lung scan.