Transient Migratory Osteoporosis

Abstract

Transient migratory osteoporosis is characterized by the acute onset of migratory pain at weight-bearing joints. The diagnosis is based on clinical findings together with characteristic abnormalities on MRI or bone scan. Each attack is generally self-limiting but may take several months to resolve. We describe 2 cases of transient migratory osteoporosis to highlight their rapid response to pamidronate therapy; in addition, 1 of these cases affected the sacrum, a site not reported to be involved in this condition.