Isolation and Structure Elucidation of Enniatins L, M₁, M₂, and N: Novel Hydroxy Analogs

Abstract

Abstract Four new cyclohexadepsipeptides, enniatins L ( 1 ), M 1 ( 2 ), M 2 ( 3 ), and N ( 4 ), have been isolated from an unidentified fungus (BCC 2629), together with the known enniatins B ( 5 ), H ( 6 ), and I ( 7 ), MK1688 ( 8 ), and enniatin B 4 ( 9 ). Compounds 1 – 4 are the first enniatin analogs with an OH group at the side chain of one of the 2‐hydroxycarboxylic acid residues. The structures of 1 – 4 were elucidated by spectroscopic means and by X‐ray crystallography.