Delayed Inflammatory Reaction to Hyaluronic Acid (Restylane®)

Abstract

In Brief A 45-year-old man received an injection of Restylane (cross-linked hyaluronic acid) to a mid-forehead furrow line in an attempt to reduce its prominence. The injection was uncomplicated and successful in reducing the line. Five months after the injection, he returned with an inflammatory reaction in the area of injection that resolved without treatment over a period of 3 weeks. Five months after an uncomplicated injection of Restylane to a forehead line, an inflammatory reaction developed that resolved without treatment over a 3-week period.