Concepedia

Publication | Closed Access

Protective Effects of Corticosteroids in Contrast Material Anaphylaxis

DOI

20

Citations

0

References

1988

Year

E. C. LASSER, C. C. BERRY, L. B. Talner, L. C. SANTINI, E. K. LANG, F. H. GERBER, H. O. STOLBERG
Investigative Radiology

Abstract

A prospective, randomized study of the potential protective effects of corticosteroids administered as pretreatment against contrast material (CM) reactions is reported. Patients (n = 6,763) from multiple institutions received either a single dose of steroids (32 mg of oral methylprednisolone, approximately 2 hours before CM challenge), a double dose (32 mg approximately 12 hours and 2 hours before CM challenge), or placebo. All contrast injections were with ionic media and were given intravenously. The two-dose (but not the one-dose) corticosteroid regimen provided significant protection. The effect on reaction incidences of a number of historical variables is also tabulated.