The Correlation of p53 Protein Overexpression and p53 Antibodies in Serum of Patients with Transitional Cell Carcinoma of the Urinary Bladder

Abstract

This study shows a strong relationship between p53 protein overexpression and the occurrence of p53 autoantibody in bladder cancer. The expression of p53 autoantibodies seems to be an event in cases of bladder cancer with an unfavorable tumor-specific outcome. Because of the small number of cases and the short follow-up time, further quantitative studies will hopefully demonstrate whether this might be of prognostic importance.