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X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design

X-ray CrystallographyBiochemistryX-ray StructureNatural SciencesDual-site Inhibitor DesignProtein X-ray CrystallographyMolecular BiologyStructure-function Enzyme KineticsTernary Mtx·nadph ComplexChemical BiologyMedicineMolecular ModelingStructural BiologyDrug Discovery