Lung cancer susceptibility in relation to combined polymorphisms of microsomal epoxide hydrolase and glutathione S-transferase P1

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

Peter Sims, P.L. Grover, Alan Swaisland et al. · Nature · 1974 · 1.1K citations

Life Sciences, Biochemistry, Metabolism +12

Human microsomal epoxide hydrolase: genetic poloymorphism and functional expression in <i>vitro</i> of amino acid variants

Christopher Hassett, Lauri Alcher, Jaspreet S. Sidhu et al. · Human Molecular Genetics · 1994 · 496 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Naturally Occurring Human Glutathione <i>S</i>‐transferase GSTP1‐1 Isoforms with Isoleucine and Valine in Position 104 Differ in Enzymic Properties

Piotr Zimniak, Bindu Nanduri, Sławomir Pikuła et al. · European Journal of Biochemistry · 1994 · 454 citations

Life Sciences, Biochemistry, Molecular Biology +12

Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema

Christopher A. Smith, David J. Harrison · The Lancet · 1997 · 435 citations

Life Sciences, Genetics, Molecular Genetics +8

Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons

Kathrin Sundberg · Carcinogenesis · 1998 · 321 citations · Full text

Medicine, Biochemistry, Oncology +14