Pancreatic Islet-Acinar Cell Interaction: Amylase Messenger RNA Levels Are Determined By Insulin

Abstract

Pancreatic amylase messenger RNA progressively decreases in rats rendered diabetic with streptozotocin. Insulin reverses this effect, inducing a selective decrease in amylase messenger RNA in the pancreas. Parotid amylase messenger RNA is not significantly affected by either diabetes or insulin.