Monoacylglycerol Lipase Inhibition Blocks Chronic Stress-Induced Depressive-Like Behaviors via Activation of mTOR Signaling

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Luca Santarelli, Michael Saxe, Cornelius T. Gross et al. · Science · 2003 · 4.3K citations · Full text

Medicine, Neurobiology, Neuroscience +16

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Nanxin Li, Boyoung Lee, Rongjian Liu et al. · Science · 2010 · 2.9K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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Life Sciences, Biochemistry, Neuroscience +14

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Paul Willner, Anthony Towell, D. Sampson et al. · Psychopharmacology · 1987 · 2K citations

Medicine, Behavioral Sciences, Pharmacology +15