Proceedings of the National Academy of Sciences · 1986 · 121 citations · 24 references
Life SciencesGeneticsMolecular GeneticsHuman GeneticsImmunogeneticsMedical GeneticsGene LinkageGene MappingGenetic DisordersGenetic LinkageLinkage AnalysisMuscular DystrophyChronic Granulomatous DiseaseCloningDna ProbesDuchenne Muscular Dystrophy InheritanceGene Mapping In FamiliesGene Mapping In PedigreesGenetic Linkage AnalysisX-linked Linkage Analysis
Chronic granulomatous disease (CGD) is a disorder of phagocytes that is usually inherited as an X chromosome-linked trait. Previous family studies suggested that the CGD locus resides on the distal short arm (Xp22-Xpter). Using cloned, polymorphic DNA probes we have performed a linkage analysis within CGD families that suggests a more proximal location (Xp21). In addition, the CGD locus is proximal to the Duchenne muscular dystrophy locus and lies within a broad region of Xp in which recombination appears to be greater than anticipated on the basis of physical distance between markers. Regional localization of the X chromosome CGD locus should facilitate molecular cloning of the CGD gene and molecular dissection of the phagocyte oxidase system.
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A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES
M. Seabright · The Lancet · 1971 · 5K citations
Easy calculations of lod scores and genetic risks on small computers.
G.M. Lathrop, J.-M. Lalouel · PubMed · 1984 · 1.5K citations