Variants in <i>TNFAIP3</i>, <i>STAT4</i>, and <i>C12orf30</i> loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis

Abstract

We have demonstrated associations between JIA and variants in the TNFAIP3, STAT4, and C12orf30 regions that have previously shown associations with other autoimmune diseases, including RA and systemic lupus erythematosus. Our results suggest that clinically distinct autoimmune phenotypes share common genetic susceptibility factors.