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The Effect of Spironolactone on Antipyrine Metabolism in Man
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1973
Year
Molecular PharmacologyAntipyrine MetabolismMedicinePhysiologyIncreased ExcretionClinical PharmacologyExcretion RatePharmacotherapyEndocrinologyPlasma Antipyrine Half-lifeExperimental PharmacologyMetabolismPharmacologySteroid MetabolismReproductive Endocrinology
Spironolactone treatment was associated with a decrease in the plasma antipyrine half-life in all 9 volunteers studied. This was associated with an increased excretion of 4-OH antipyrine but not 3-hydroxymethyl antipyrine in their urine. The plasma antipyrine disappearance rate correlated with the excretion rate of 4-OH antipyrine in the urine. Spironolactone increased the excretion of 6-β OH cortisol in the urine. These data provided indirect evidence that spironolactone is an inducer of hepatic drug hydroxylation in man.