Activation of H₂O₂ by Chiral Confined Brønsted Acids: A Highly Enantioselective Catalytic Sulfoxidation

Abstract

Confined chiral Brønsted acids are shown to catalyze asymmetric oxidations of sulfides to sulfoxides with hydrogen peroxide. The wide generality and high enantioselectivity of the developed method compare even to the best metal-based systems and suggest utility in other asymmetric oxidations.