Induction and Maintenance of Ethanol Self‐Administration in Cynomolgus Monkeys (<i>Macaca fascicularis</i>): Long‐Term Characterization of Sex and Individual Differences

Abstract

Cynomolgus monkeys displayed a wide intersubject range of oral ethanol self-administration with a procedure that used a uniform and prolonged induction that restricted early exposure to ethanol and subsequently allowed unlimited access to ethanol. There were sex and stable individual differences in the propensity of monkeys to consume ethanol, indicating that this species will be important in characterizing risk factors associated with heavy-drinking phenotypes.