Publication | Open Access
Benzylpiperazine derivatives. IV. Syntheses and cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazine derivatives.
25
Citations
0
References
1987
Year
Stronger PotencyOrganic ChemistryPharmacotherapyCerebral Vasodilating ActivitiesPharmaceutical ChemistryChemical DerivativeMedicinal ChemistryPharmacological StudyNeurologyPotent Analog 19BiochemistryBenzylpiperazine DerivativesPharmacological AgentNeuropharmacologyCerebral Vasodilating ActivityPharmacologyNatural Sciences1-Benzyl-4-diphenylmethylpiperazine DerivativesMedicineDerivative (Chemistry)Drug Discovery
A series of 1-benzyl-4-diphenylmethylpiperazines was prepared and tested for cerebral vasodilating activity. Among the compounds with stronger potency and longer-lasting action than papaverine, the most potent analog 19 (KB-2796) was selected for further study. Some pharmacological properties of 19 are presented.