Interferon-γ and Tumor Necrosis Factor-α Sustain Secretion of Specific CXC Chemokines in Human Thyrocytes: A First Step Toward a Differentiation between Autoimmune and Tumor-Related Inflammation?

Abstract

These results confirm that human thyrocytes secrete CXC chemokines and demonstrate that the secretion of CXCL8 and CXCL10 is sustained by specific proinflammatory cytokines or their combination, which ultimately determines the nature of the infiltrating lymphocytes in human thyroid diseases. These results indirectly support a major role for CXCL10 in thyroid autoimmunity whereas CXCL8 might be involved in tumor-related inflammation.