Synthesis · 2009 · 13 citations · 0 references
PharmacyBiochemistryMedicinal ChemistryDrug DesignDrug DiscoveryEnzymologyAntiviral TherapyEnzyme InhibitionPeptide ChemistryPeptide Drug DiscoveryPeptidomimetic DesignProteolytic EnzymesChronic Liver FailurePeptide Drug DevelopmentPeptide Medicinal ChemistryPeptidomimetic Library SynthesisProtease InhibitorsProteolytic PathwaysSerine-targeted Inhibitors
Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel class of peptide mimetic compounds as potential HCV serine protease inhibitors.