Synthesis of Triazole‐Epothilones by Using Cu₂O Nanoparticles to Catalyze 1,3‐Dipolar Cycloaddition

Abstract

Abstract We report the total synthesis of a triazole‐epothilone analogue 1 . The key step to generate the macrocyclic ring and the triazole ring was to apply Cu 2 O nanoparticles (Cu 2 O‐NPs) to catalyze the 1,3‐dipolar cycloaddition. The conformation of 1 and its bioactivity in MCF cancer cell lines were investigated.