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Direct structural analysis of 2-aminoacridone derivatized oligosaccharides by high-performance liquid chromatography/mass spectrometric detection
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1998
Year
EngineeringGlycosylationBiochemistryBioanalysisMass SpectrometryGlycobiologyAnalytical ChemistryPolysaccharideCarbohydrate-protein InteractionSequence InformationLiquid ChromatographyDirect Structural AnalysisMedicineChromatographic AnalysisTandem Mass SpectraBiomolecular EngineeringChromatographySimple Fragmentation Patterns
In this preliminary study linear and branched oligosaccharides, derivatized with 2-aminoacridone, have been separated by reverse-phase high-performance liquid chromatography, and detected by positive-ion electrospray mass spectrometry. Tandem Mass spectra of the protonated carbohydrate analytes gave simple fragmentation patterns from which sequence information could be readily obtained.