Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells

Iron-Chelating Therapy and the Treatment of Thalassemia

Nancy F. Olivieri, Gary M. Brittenham · Blood · 1997 · 1.1K citations · Full text

Medicine, Hematology, Pharmacotherapy +12

The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents

EH Tran, Prem Ponka · Blood · 1995 · 349 citations

Medicine, Medicinal Chemistry, Pharmacology +10

The Potential of Iron Chelators of the Pyridoxal Isonicotinoyl Hydrazone Class as Effective Antiproliferative Agents II: The Mechanism of Action of Ligands Derived From Salicylaldehyde Benzoyl Hydrazone and 2-Hydroxy-1-Naphthylaldehyde Benzoyl Hydrazone

Des R. Richardson, K. Milnes · Blood · 1997 · 208 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

A study of intracellular iron metabolism using pyridoxal isonicotinoyl hydrazone and other synthetic chelating agents

Přemysl Poňka, J Borová, J Neuwirt et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 1979 · 188 citations

Medicine, Biochemistry, Pharmacology +13

Studies in Desferrioxamine and Ferrioxamine Metabolism in Normal and Iron‐Loaded Subjects

MJ Summers, Alice K. Jacobs, D.C. Tudway et al. · British Journal of Haematology · 1979 · 182 citations

Medicine, Pharmacokinetics, Pharmacology +14