Solubility of 11α-Hydroxy-16α,17α-Epoxyprogesterone in Different Solvents between 283 K and 323 K

Abstract

The solubilities of 11α-hydroxy-16α,17α-epoxyprogesterone in methanol, ethanol, acetone, ethyl acetate, and acetic acid were measured using an isothermal method from 283 K to 323 K. A laser monitoring observation technique was used to determine the dissolution of the solid phase in a solid + liquid mixture. The solubility of 11α-hydroxy-16α,17α-epoxyprogesterone in the above solvents increased in the order ethanol < methanol < ethyl acetate < acetone < acetic acid. The experimental solubility data was correlated with a semiempirical equation.