Studies on the metabolites of Verticillium sp. Structures of verticillins A, B, and C

Abstract

Three new antibiotics, verticillins A (Ia), B (XVIII), and C have been isolated from Verticillium sp. Stereo-structures of verticillins A and B, which are derivatives of bi-(3,11 a-epidithio-1.4-dioxopyrazino[1′,2′ : 1,5]pyrrolo-[2,3-b]indol-10b-yl), have been elucidated by chemical and physicochemical methods. Verticillin C is thought to be an epitrithio-analogue of verticillin B.