Synthesis of 14,20-Bis-epi-1α,25-dihydroxy-19-norvitamin D3 and Analogues

Abstract

14,20-Bis-epi-1α,25-dihydroxy-19-norvitamin D3 and side chain analogues thereof have been synthesised via the 14,20-bis-epi-Inhoffen–Lythgoe diol 9. The synthesis of this precursor was performed via degradation of vitamin D2 and by total synthesis starting from Hajos–Wiechert ketone 24.