Concepedia

Publication | Open Access

Prediction of Irinotecan Pharmacokinetics by Use of Cytochrome P450 3A4 Phenotyping Probes

DOIFull Paper Access

124

Citations

47

References

2004

Year

Ron H.J. Mathijssen, Floris A. de Jong, Ron H. N. van Schaik, Erin R. Lepper, Lena E. Friberg, T. Rietveld, Peter de Bruijn, Wilfried J. Graveland, William D. Figg, J. Verweij,
JNCI Journal of the National Cancer Institute

Abstract

CYP3A4 phenotype, as assessed by midazolam clearance, is statistically significantly associated with irinotecan pharmacokinetics. Evaluation of midazolam clearance combined with UGT1A1*28 genotyping may assist with optimization of irinotecan chemotherapy.

References

YearCitations

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