Simulation Study of Hemodynamics of Red Blood Cells in Stenotic Microvessels

Abstract

The shape and mechanical properties of abnormal red blood cells (RBCs) change considerably in comparison with healthy red blood cells (RBCs). In this paper, we perform numerical investigation of the hemodynamics of RBCs in microvessels with stenosis. Our model is based on an immersed boundary-fictitious domain method. We employ a spring model for representing deformability of RBC membrane. The proposed model successfully simulates complex motion and deformation of RBCs in micro scale flow. Our method would be helpful for further understandings of pathology of malaria and some other blood disorders.