TiCl₄, Dioxane—A Facile and Efficient System for De-<i>O</i>-Benzylation, De-<i>O</i>-Allylation, and De-<i>O</i>-Xylylation of Phenolic Ethers

Abstract

Abstract Simultaneous de-O-xylylation and reductive coupling was observed when 1 equiv. of the dialdehyde 2a/2b was treated with 5 equiv. of each TiCl4 and Zinc which lead to the development of TiCl4 in dioxane as a new system for the facile deprotection of phenolic ethers 4a–4d, 5a–5d, and 6a–6c.