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Chemistry of the phenoxathiins i. Synthesis of 1‐azaphenoxathiin analogs as potential new CNS depressant agents
27
Citations
6
References
1977
Year
Pharmaceutical ScienceOrganic ChemistryPharmacotherapyChemistryFourier Transform 1Heterocycle ChemistryPhenoxathiins I. SynthesisPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryDisodium SaltBiochemistryPharmacological AgentNeuropharmacologyPharmacologyNatural SciencesDrug DiscoveryMedicineSynthetic Pathway
Abstract The condensation of the disodium salt of 2‐mercapto‐3‐pyridinol with various ortho ‐nitrohalo‐benzenes to yield a group of previously unreported 1‐azaphenoxathiins is described. The synthetic pathway and the substituent location on the products is unequivocably demonstrated by Fourier Transform 1 3 C‐nmr. Preliminary pharmacologic evaluation of the title compounds as potential CNS depressant agents is also reported.
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