Thrombolysis and Reocclusion in Experimental Jugular Vein and Coronary Artery Thrombosis

Abstract

Administration of the anti-PAI-1 antibody (CLB-2C8) results in increased endogenous thrombolysis and inhibition of thrombus growth in a venous thrombosis model in rabbits and facilitated reperfusion and reduction of reocclusion in a canine model of coronary artery thrombosis.