A Total Synthesis of (+)-Geodiamolides A and B, the Novel Cyclodesiprptides

Abstract

Diastereo-controlled total synthesis of (+)-geodiamolides A ' ~-~m r (CDC13) S 0 . 1 7 ( 6 H . s , S i M e 2 ) , 0 .9 7 ( 9 H , s , S i -t -B u l , 2 .3 5 ( 3 H , s , NMel, 2 . 8 7 -2. 9 0 ( 2H , m , T ~~P C H ~) , 3 .4 4 ( 1 H . t , J = 6.84 H z , T y r *CHI, 5 .0 8 ( Z H , d d , J = 1 2 . 2 1 a n d 1 5 . 1 4 Hz, C 0 2 C g 2 P h ) , 6.71 ( 2 H , d , J = 8 .3 0 H z , T y r C3-H a n d C5-H), 6 .9 1 ( 2 H , J = 8.30 H z , T y r C2-H a n d C6-HI, 7 .2 2 -7 .3 4 ( 5 H , m, C 0 2 C H 2 a ) .m. C