Myeloid Stem Cell Kinetics during Erythropoietic Stress

Abstract

S ummary . The committed myeloid stem cell compartment, monitored by the agar colony technique, has been assayed in the bone marrow, spleen and blood of mice during erythropoietic stress. When red cell production appeared maximal, the size of the committed myeloid stem cell comparment was reduced in the bone marrow and there was usually a reciprocal rise in the spleen with varying numbers of these cells in the circulation. The role of stem cell competition and migration in the development of these changes is discussed.