Time Course of Effects of Testosterone Administration on Sexual Arousal in Women

TLDR

Assumptions about testosterone’s role in female sexual function stem mainly from studies of women with hypogonadotropic hypogonadism. The study aimed to assess whether a single sublingual dose of testosterone increases physiological and subjective sexual arousal in sexually functional women during exposure to erotic stimuli. Eight healthy women received a single sublingual dose of testosterone and were exposed to six erotic film excerpts at specified intervals; plasma testosterone rose sharply within 15 minutes and returned to baseline within 90 minutes. Testosterone produced a delayed increase in genital responsiveness 3–4½ hours after peak levels, which correlated with heightened genital sensations and sexual lust, indicating a time lag in its effect on sexual arousal.

Abstract

The assumption that testosterone is involved in human female sexual functioning is mainly based on results of studies of women with hypogonadotropic hypogonadism. This study sought to determine the effect of testosterone administration on physiological and subjective sexual arousal in sexually functional women.In a double-masked, randomly assigned, placebo-controlled crossover design, we examined whether administration of a single dose of testosterone to sexually functional women increases vaginal and subjective sexual arousal when they are exposed to erotic visual stimuli. To search for a time lag in the effect of testosterone therapy, we exposed 8 healthy women to 6 erotic film excerpts depicting intercourse. The first and second excerpts were shown immediately before and 15 minutes after, respectively, intake of placebo or testosterone; the last 4 excerpts were then shown at 1(1/2)-hour intervals.Sublingual intake of testosterone caused a sharp increase in plasma testosterone levels within 15 minutes; these levels declined to baseline values within 90 minutes. Three to 4(1/2) hours after reaching peak testosterone level, we found a statistically significantly increase in genital responsiveness (P = .04). Furthermore, on the day of testosterone treatment, there also was a strong and statistically significant association between the increase in genital arousal and subjective reports of "genital sensations" (P = .02) and "sexual lust" (P = .01) after 4(1/2) hours.There is a time lag in the effect of sublingually administered testosterone on genital arousal in women. In addition, a consecutive increase in vaginal arousal might cause higher genital sensations and sexual lust.