Au(I)-Catalyzed Rearrangement Reaction of Propargylic Aziridine: Synthesis of Trisubstituted and Cycloalkene-Fused Pyrroles

Abstract

A rearrangement reaction of propargylic aziridine, catalyzed by PPh(3)AuCl/AgOTf, forming trisubstituted and cycloalkene-fused pyrroles is described which involves an unusual tandem cyclization/ring-opening/Wagner-Meerwein process. The unique structures of the products demonstrated its potential applications for synthesizing structurally diverse alkaloids.