Concepedia

Xenon Impairs Neurocognitive and Histologic Outcome after Cardiopulmonary Bypass Combined with Cerebral Air Embolism in Rats

Bettina Jungwirth, M. L. Gordan, Manfred Blobner, W. R. Schmehl, E. Kochs, G. Burkhard Mackensen

Anesthesiology · 2006 · 36 citations · 16 references

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Abstract

This is the first demonstration in which the neurologic effects of CAE have been examined in a rat model of CPB. Xenon exposure aggravated the neurologic dysfunction that is produced by CAE during CPB; potential neuroprotective effects of xenon may have been masked by the effects of xenon on CAE.

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Xenon Attenuates Cardiopulmonary Bypass–induced Neurologic and Neurocognitive Dysfunction in the Rat

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