Xenon Impairs Neurocognitive and Histologic Outcome after Cardiopulmonary Bypass Combined with Cerebral Air Embolism in Rats

Abstract

This is the first demonstration in which the neurologic effects of CAE have been examined in a rat model of CPB. Xenon exposure aggravated the neurologic dysfunction that is produced by CAE during CPB; potential neuroprotective effects of xenon may have been masked by the effects of xenon on CAE.

References

Page 1

	Year	Citations
Longitudinal Assessment of Neurocognitive Function after Coronary-Artery Bypass Surgery Mark F. Newman, Jerry Kirchner, Vincent Gaver, New England Journal of Medicine	2001	1.9K
The Anesthetic Properties of Xenon in Animals and Human Beings, with Additional Observations on Krypton Stuart C. Cullen, Erwin G. Gross Science Additional ObservationsMedicinePhysiologyAnesthetic MechanismAnesthetic Properties	1951	453
The Neuroprotective Effect of Xenon Administration during Transient Middle Cerebral Artery Occlusion in Mice H. Mayumi Homi, Noriko Yokoo, Daqing Ma, Anesthesiology	2003	175
Xenon Attenuates Cardiopulmonary Bypass–induced Neurologic and Neurocognitive Dysfunction in the Rat Daqing Ma, Hong Yang, John Lynch, Anesthesiology	2003	154
Neuroprotective and neurotoxic properties of the 'inert' gas, xenon Daqing Ma British Journal of Anaesthesia NeurotoxicologyNeurotoxic PropertiesNeurophysiologyMedicineNeurotransmitter	2002	144
Cardiovascular Effects of Xenon in Isoflurane-anesthetized Dogs with Dilated Cardiomyopathy Douglas A. Hettrick, Paul S. Pagel, Judy R. Kersten, Anesthesiology	1998	126
Xenon Provides Faster Emergence from Anesthesia than Does Nitrous Oxide-sevoflurane or Nitrous Oxide-isoflurane Takahisa Goto, Hayato Saito, Yoshinori Nakata, Anesthesiology	1997	106
Exploration of xenon as a potential cardiostable sedative: a comparison with propofol after cardiac surgery John Dingley, R. King, L. Hughes, Anaesthesia	2001	81
Cardiopulmonary Bypass Induces Neurologic and Neurocognitive Dysfunction in the Rat G. Burkhard Mackensen, Yukie Sato, Bengt Nellgård, Anesthesiology	2001	79
Cognitive performance in rats differing in their inborn anxiety. Frauke Ohl, Angelika Roedel, Corinna Storch, Behavioral Neuroscience NeuropsychologyDevelopmental Cognitive NeuroscienceAffective NeuroscienceSocial SciencesPsychology	2002	56

Page 1