Publication | Closed Access
COMPARISON OF THE HYPOGLYCEMIC ACTION OF TOLBUTAMIDE IN THE FOWL AND OTHER SPECIES12
23
Citations
0
References
1957
Year
Veterinary ResearchEducationBlood SugarInsulin SignalingLaboratory Animal StudyGastrointestinal Peptide HormoneBeta CellsMetabolic SyndromeToxicologyAnimal PhysiologyVeterinary PhysiologyBiochemistryAnimal NutritionInsulin ManagementImmediate Hypoglycemic ResponseEndocrinologyPharmacologyAnimal SciencePoultry DiseasePhysiologyDiabetesVeterinary ScienceAnimal HealthDiabetes MellitusMetabolismMedicinePoultry Science
THE immediate hypoglycemic response to the aryl sulfonylureas, 1-buty1-3-p-aminobenzene-sulfonylurea (BZ-55, Carbutamide), 1-butyl-3-p-tolylsulfonylurea (U-2043, Tolbutamide, Orinase) and related compounds (eg., p-amino-sulfonamide-isopropylthiodiazole) is dependent upon the presence of beta cells in the islets of Langerhans of the pancreas of man (1, 2, 3, 4), dog (5, 6, 7), rabit (8,9), rat (10, 11) and toad (7). Accordingly, it is generally agreed that irrespective of the precise manner whereby the sulfonylureas exert their hypoglycemic action, the secretion of insulin by the pancreas is involved. The aforementioned species develop hyperglycemia and other manifestations of diabetes mellitus after ablation or destruction of the islet tissue. Since pancreatectomy does not produce similar changes in the duck or chicken (12, 13), it became pertinent to investigate the effect of the sulfonylureas on the blood sugar of normal and depancreatized fowl. Chickens and Pekin ducks of from 1.5 to 3.0 kg. in weight were used in this study.