HLA-C and Killer Cell Immunoglobulin-like Receptor Genes in Idiopathic Bronchiectasis

Abstract

This is the first demonstration of genetic susceptibility in idiopathic bronchiectasis. The association with HLA-C group 1 homozygosity, and the interplay between HLA-C and KIR genes, argue for a role for NK cells in the progressive lung damage seen in this disease. This will require further investigation using functional studies.