New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

Medicine, Pharmacology, Clinical Pharmacology +7

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

Claire Bombardier, Loren Laine, Alise Reicin et al. · New England Journal of Medicine · 2000 · 4K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +8

Gastrointestinal Toxicity With Celecoxib vs Nonsteroidal Anti-inflammatory Drugs for Osteoarthritis and Rheumatoid Arthritis

Fred E. Silverstein, Gerald A. Faich, Jay L. Goldstein et al. · JAMA · 2000 · 3.2K citations

Medicine, Pharmacology, Pharmacotherapy +16

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

Dean A. Kujubu, Bradley S. Fletcher, Brian Varnum et al. · Journal of Biological Chemistry · 1991 · 1.8K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14