Interaction of Amorphous Silica Nanoparticles with Erythrocytes<b><i>in Vitro</i></b>: Role of Oxidative Stress

Abstract

It can be concluded that SiNP cause a dose-dependent hemolytic activity and are taken up by the erythrocytes. We also found that SiNP induce the occurrence of oxidative activity, apoptosis and increase cytosolic Ca(2+), which may explain their haemolytic activity. Our in vitro data suggest that SiNP may, plausibly, lead to anemia and circulatory disorders in vivo.