Site‐Selective Ser‐Hydrolase Labelling with a Luminescent Organometallic NCN–Platinum Complex

Abstract

Abstract The synthesis, spectroscopic properties and protein‐binding studies of a novel luminescent organometallic NCN–platinum complex are described. The luminescent organometallic complex was linked to a serine hydrolase reactive phosphonate group by means of click chemistry, and was exploited in serine hydrolase specific‐binding studies using gel electrophoresis. The NCN–platinum protein label was found to be a robust dye with absorbance and emission maxima between 374–380 and 482–493 nm, respectively, and quantum yields between 0.04 and 0.15.