Disruption of Contact Lens–Associated<i>Pseudomonas aeruginosa</i>Biofilms Formed in the Presence of Neutrophils

Abstract

These results demonstrate that PA can exploit the presence of neutrophils to form biofilm on contact lenses within a short time. Incorporation of F-actin and DNA represent a mechanism for neutrophil-induced biofilm enhancement and are targets for available agents to disrupt pathogenic biofilms formed on contact lenses and as a treatment for established corneal infections.