Regulation of Skin and Islet Allograft Survival in Mice Treated With Costimulation Blockade is Mediated by Different CD4+ Cell Subsets and Different Mechanisms

Abstract

These data document that (1) both CD4CD25 and CD4CD25 cells are required for induction of skin allograft survival, (2) CD4CD25 T cells are not required for alloreactive CD8 T cell deletion, and (3) CD4CD25 regulatory cells are not critical for islet allograft tolerance. It appears that skin and islet transplantation tolerance are mediated by different CD4 cell subsets and different mechanisms.